DdCBE mediates efficient and inheritable modifications in mouse mitochondrial genome

• Main Authors: Jiayin Guo (Author), Xiaoxu Chen (Author), Zhiwei Liu (Author), Haifeng Sun (Author), Yu Zhou (Author), Yichen Dai (Author), Yu'e Ma (Author), Lei He (Author), Xuezhen Qian (Author), Jianying Wang (Author), Jie Zhang (Author), Yichen Zhu (Author), Jun Zhang (Author), Bin Shen (Author), Fei Zhou (Author)
• Format: Book
• Published: Elsevier, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Critical mutations of mitochondrial DNA (mtDNA) generally lead to maternally inheritable diseases that affect multiple organs and systems; however, it was difficult to alter mtDNA in mammalian cells to intervene in or cure mitochondrial disorders. Recently, the discovery of DddA-derived cytosine bas...