Improved method for synthesis of low molecular weight protamine-siRNA conjugate

• Main Authors: Zhili Yu (Author), Junxiao Ye (Author), Xing Pei (Author), Lu Sun (Author), Ergang Liu (Author), Jianxin Wang (Author), Yongzhuo Huang (Author), Seung Jin Lee (Author), Huining He (Author)
• Format: Book
• Published: Elsevier, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

RNAi technology has aroused wide public interest due to its high efficiency and specificity to treat multiple types of diseases. However, the effective delivery of siRNA remains a challenge due to its large molecular weight and strong anionic charge. Considering their remarkable functions in vivo an...