Tacrolimus pharmacokinetics in pediatric nephrotic syndrome: A combination of population pharmacokinetic modelling and machine learning approaches to improve individual prediction

• Main Authors: Qiongbo Huang (Author), Xiaobin Lin (Author), Yang Wang (Author), Xiujuan Chen (Author), Wei Zheng (Author), Xiaoli Zhong (Author), Dewei Shang (Author), Min Huang (Author), Xia Gao (Author), Hui Deng (Author), Jiali Li (Author), Fangling Zeng (Author), Xiaolan Mo (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background and Aim: Tacrolimus (TAC) is a first-line immunosuppressant for the treatment of refractory nephrotic syndrome (RNS), but the pharmacokinetics of TAC varies widely among individuals, and there is still no accurate model to predict the pharmacokinetics of TAC in RNS. Therefore, this study...