Pyrancoumarin derivative LP4C targeting of pyrimidine de novo synthesis pathway inhibits MRSA biofilm and virulence

• Main Authors: Yongsheng Liu (Author), Shan Su (Author), Moxi Yu (Author), Dongshen Zhai (Author), Yachen Hou (Author), Hui Zhao (Author), Xue Ma (Author), Min Jia (Author), Xiaoyan Xue (Author), Mingkai Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Staphylococcus aureus poses a serious public health threat because of its multidrug resistance and biofilm formation ability. Hence, developing novel anti-biofilm agents and finding targets are needed to mitigate the proliferation of drug-resistant pathogens. In our previous study, we showed that th...