Hypertension related toxicity of chloroquine explains its failure against COVID-19: Based on rat model

• Main Authors: Junqi Wang (Author), Xian Jing (Author), Lizhong Hua (Author), Yuling Zheng (Author), Shiheng Hu (Author), Jing Xiao (Author), Dawei Guo (Author), Wenda Wu (Author), Hui Ji (Author), Lin Peng (Author), Shanxiang Jiang (Author), Xiuge Gao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chloroquine was once thought to be a promising treatment for COVID-19 but it quickly failed due to its inefficiency and association with increased mortality. Further, comorbidities such as hypertension may have contributed this failure. The safety and toxicity of chloroquine at doses required for tr...