Influence of the Fatty Acid Metabolism on the Mode of Action of a Cisplatin(IV) Complex with Phenylbutyrate as Axial Ligands

• Main Authors: Theresa Mendrina (Author), Isabella Poetsch (Author), Hemma Schueffl (Author), Dina Baier (Author), Christine Pirker (Author), Alexander Ries (Author), Bernhard K. Keppler (Author), Christian R. Kowol (Author), Dan Gibson (Author), Michael Grusch (Author), Walter Berger (Author), Petra Heffeter (Author)
• Format: Book
• Published: MDPI AG, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

For a variety of cancer types, platinum compounds are still among the best treatment options. However, their application is limited by side effects and drug resistance. Consequently, multi-targeted platinum(IV) prodrugs that target specific traits of the malignant tissue are interesting new candidat...