Necrostatin-1 Prevents Ferroptosis in a RIPK1- and IDO-Independent Manner in Hepatocellular Carcinoma

• Главные авторы: Hanna Yuk (Автор), Md Abdullah (Автор), Do-Hyung Kim (Автор), Haeseung Lee (Автор), Seung-Jin Lee (Автор)
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• Опубликовано: MDPI AG, 2021-08-01T00:00:00Z.
• Предметы: article
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Ferroptosis is caused by the iron-mediated accumulation of lipid peroxidation, which is distinct from apoptosis and necroptosis. Necrostatin-1 inhibits receptor-interacting serine/threonine-protein kinase 1 (RIPK1) to initiate necroptosis; it also inhibits indoleamine 2,3-dioxygenase (IDO) to regula...