Necrostatin-1 Prevents Ferroptosis in a RIPK1- and IDO-Independent Manner in Hepatocellular Carcinoma

• 主要な著者: Hanna Yuk (著者), Md Abdullah (著者), Do-Hyung Kim (著者), Haeseung Lee (著者), Seung-Jin Lee (著者)
• フォーマット: 図書
• 出版事項: MDPI AG, 2021-08-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Ferroptosis is caused by the iron-mediated accumulation of lipid peroxidation, which is distinct from apoptosis and necroptosis. Necrostatin-1 inhibits receptor-interacting serine/threonine-protein kinase 1 (RIPK1) to initiate necroptosis; it also inhibits indoleamine 2,3-dioxygenase (IDO) to regula...