Serelaxin Elicits Bronchodilation and Enhances β-Adrenoceptor-mediated Airway Relaxation

• Main Authors: Maggie Lam (Author), Simon G Royce (Author), Chantal Donovan (Author), Maria Jelinic (Author), Laura J Parry (Author), Chrishan S Samuel (Author), Jane Elizabeth Bourke (Author)
• Format: Book
• Published: Frontiers Media S.A., 2016-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Treatment with β-adrenoceptor agonists does not fully overcome the symptoms associated with severe asthma. Serelaxin elicits potent uterine and vascular relaxation via its cognate receptor, RXFP1, and nitric oxide (NO) signaling, and is being clinically evaluated for the treatment of acute heart fai...