Progesterone Metabolism by Human and Rat Hepatic and Intestinal Tissue

• Main Authors: Zoe Coombes (Author), Katie Plant (Author), Cristina Freire (Author), Abdul W. Basit (Author), Philip Butler (Author), R. Steven Conlan (Author), Deyarina Gonzalez (Author)
• Format: Book
• Published: MDPI AG, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Following oral administration, the bioavailability of progesterone is low and highly variable. As a result, no clinically relevant, natural progesterone oral formulation is available. After oral delivery, first-pass metabolism initially occurs in the intestines; however, very little information on p...