A Novel Association of Polymorphism in the ITGA4 Gene Encoding the VLA-4 α4 Subunit with Increased Risk of Alzheimer's Disease

• Main Authors: Vladimira Durmanova (Author), Zuzana Parnicka (Author), Juraj Javor (Author), Gabriel Minarik (Author), Lubomir Vrazda (Author), Barbora Vaseckova (Author), Karin Gmitterova (Author), Maria Kralova (Author), Jan Pecenak (Author), Peter Filipcik (Author), Ivana Shawkatova (Author)
• Format: Book
• Published: Hindawi Limited, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Alzheimer's disease (AD) is the most prevalent cause of dementia in elderly people worldwide. Many studies support the hypothesis that the inflammation of the CNS contributes to the neurodegeneration and disease progression. The integrin molecule α4β1, also known as very late antigen 4 (VLA-4),...