Development and validation of a method for the determination of valproic acid in pharmaceutical formulations by high performance liquid chromatography with diode array detection (HPLC-DAD) / Desenvolvimento e validação de um método para a determinação de ácido valpróico em formulações farmacêuticas por cromatografia líquida de alta eficiência acoplada com detector de conjunto de fotodiodos

• Main Authors: Paulo Ricardo de Souza e Souza (Author), Juliana Machado de Carvalho (Author), André Luis Mazzei Albert (Author), Josino Costa Moreira (Author), Katia Christina Leandro (Author)
• Format: Book
• Published: Fundação Oswaldo Cruz (FIOCRUZ), 2013-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Valproic acid (VA) is used as an anticonvulsant and is used in the treatment of bipolar disorder and depression. The offi cial analytical method for this drug in the compendia is gas chromatography, which is unavailable in many quality control laboratories. Here, we report a validated alternative met...