α4-containing GABAA receptors are required for antagonism of ethanol-induced motor incoordination and hypnosis by the imidazobenzodiazepine Ro15-4513

• Main Authors: Sangeetha V. Iyer (Author), Rodrigo eBenavides (Author), Dev eChandra (Author), James M Cook (Author), Sundari eRallapalli (Author), Harry L. June (Author), Gregg E Homanics (Author)
• Format: Book
• Published: Frontiers Media S.A., 2011-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Alcohol (ethanol) is widely consumed for its desirable effects but unfortunately has strong addiction potential. Some imidazobenzodiazepines such as Ro15-4513 are able to antagonize many ethanol-induced behaviors. Controversial biochemical and pharmacological evidence suggest that the effects of the...