Cytotoxic Desulfated Saponin from Holothuria atra Predicted to Have High Binding Affinity to the Oncogenic Kinase PAK1: A Combined In Vitro and In Silico Study

• Auteurs principaux: Md Shahinozzaman (Auteur), Takahiro Ishii (Auteur), Ryo Takano (Auteur), Mohammad A. Halim (Auteur), Md Amzad Hossain (Auteur), Shinkichi Tawata (Auteur)
• Format: Livre
• Publié: MDPI AG, 2018-08-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Sea cucumbers have long been utilized in foods and Asiatic folk medicines for their nutritive and health benefits. Herein, three sea cucumber species were investigated and Holothuria atra showed the highest cytotoxicity among these. Next, a desulfated saponin, desulfated echinoside B (DEB), was puri...