Assessing the synergy between cholinomimetics and memantine as augmentation therapy in Cognitive Impairment in Schizophrenia. A virtual human patient trial using Quantitative Systems Pharmacology

• 主要な著者: Hugo eGeerts (著者), Athan eSpiros (著者), Patrick eRoberts (著者)
• フォーマット: 図書
• 出版事項: Frontiers Media S.A., 2015-09-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

While many drug discovery research programs aim to develop highly selective clinical candidates, their clinical success is limited because of the complex non-linear interactions of human brain neuronal circuits. Therefore a rational approach for identifying appropriate synergistic multipharmacology...