Assessing the synergy between cholinomimetics and memantine as augmentation therapy in Cognitive Impairment in Schizophrenia. A virtual human patient trial using Quantitative Systems Pharmacology

• Những tác giả chính: Hugo eGeerts (Tác giả), Athan eSpiros (Tác giả), Patrick eRoberts (Tác giả)
• Định dạng: Sách
• Được phát hành: Frontiers Media S.A., 2015-09-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.

While many drug discovery research programs aim to develop highly selective clinical candidates, their clinical success is limited because of the complex non-linear interactions of human brain neuronal circuits. Therefore a rational approach for identifying appropriate synergistic multipharmacology...