Interaction Between Sex and Organic Anion‐Transporting Polypeptide 1b2 on the Pharmacokinetics of Regorafenib and Its Metabolites Regorafenib‐N‐Oxide and Regorafenib‐Glucuronide in Mice

• Main Authors: Qiang Fu (Author), Mingqing Chen (Author), Jason T. Anderson (Author), Xinxin Sun (Author), Shuiying Hu (Author), Alex Sparreboom (Author), Sharyn D. Baker (Author)
• Format: Book
• Published: Wiley, 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Regorafenib, a multikinase inhibitor used in the treatment of various solid tumors, undergoes extensive uridine 5'‐diphosphate glucuronosyltransferase (Ugt)1a9‐mediated glucuronidation to form regorafenib‐N‐β‐glucuronide (M7; RG), but the contribution of hepatic uptake transporters, such as org...