Identification of endothelin-converting enzyme-2 as an autoantigen in autoimmune polyendocrine syndrome type 1

• Main Authors: Casey J. A. Smith-Anttila (Author), Sophie Bensing (Author), Mohammad Alimohammadi (Author), Frida Dalin (Author), Mikael Oscarson (Author), Ming-Dong Zhang (Author), Jaakko Perheentupa (Author), Eystein S. Husebye (Author), Jan Gustafsson (Author), Peyman Björklund (Author), Anette Fransson (Author), Gunnel Nordmark (Author), Lars Rönnblom (Author), Antonella Meloni (Author), Rodney J. Scott (Author), Tomas Hökfelt (Author), Patricia A. Crock (Author), Olle Kämpe (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Autoimmune polyendocrine syndrome type 1 (APS1) is a rare monogenic autoimmune disorder caused by mutations in the autoimmune regulator (AIRE) gene. High titer autoantibodies are a characteristic feature of APS1 and are often associated with particular disease manifestations. Pituitary deficits are...