Monitoring of inflammation using novel biosensor mouse model reveals tissue- and sex-specific responses to Western diet

• Main Authors: Sarah Talley (Author), Raiza Bonomo (Author), Chaitanya Gavini (Author), Jomana Hatahet (Author), Emily Gornick (Author), Tyler Cook (Author), Byeong Jae Chun (Author), Pete Kekenes-Huskey (Author), Gregory Aubert (Author), Edward Campbell (Author), Virginie Mansuy-Aubert (Author)
• Format: Book
• Published: The Company of Biologists, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Obesity is an epidemic, and it is characterized by a state of low-grade systemic inflammation. A key component of inflammation is the activation of inflammasomes, multiprotein complexes that form in response to danger signals and that lead to activation of caspase-1. Previous studies have found that...