Characterization of TR‐107, a novel chemical activator of the human mitochondrial protease ClpP

Abstract We recently described the identification of a new class of small‐molecule activators of the mitochondrial protease ClpP. These compounds synthesized by Madera Therapeutics showed increased potency of cancer growth inhibition over the related compound ONC201. In this study, we describe chemi...

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Main Authors: Emily M. J. Fennell (Author), Lucas J. Aponte‐Collazo (Author), Joshua D. Wynn (Author), Kristina Drizyte‐Miller (Author), Elisa Leung (Author), Yoshimi Endo Greer (Author), Paul R. Graves (Author), Andrew A. Iwanowicz (Author), Hani Ashamalla (Author), Ekhson Holmuhamedov (Author), Henk Lang (Author), Donald S. Karanewsky (Author), Channing J. Der (Author), Walid A. Houry (Author), Stanley Lipkowitz (Author), Edwin J. Iwanowicz (Author), Lee M. Graves (Author)
Format: Book
Published: Wiley, 2022-08-01T00:00:00Z.
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