AP-1 Oligodeoxynucleotides Reduce Aortic Elastolysis in a Murine Model of Marfan Syndrome

• Main Authors: Rawa Arif (Author), Marcin Zaradzki (Author), Anca Remes (Author), Philipp Seppelt (Author), Reiner Kunze (Author), Hannes Schröder (Author), Simon Schwill (Author), Stephan M. Ensminger (Author), Peter N. Robinson (Author), Matthias Karck (Author), Oliver J. Müller (Author), Markus Hecker (Author), Andreas H. Wagner (Author), Klaus Kallenbach (Author)
• Format: Book
• Published: Elsevier, 2017-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Marfan syndrome is characterized by high expression of matrix metalloproteinases (MMPs) in aortic smooth muscle cells (AoSMCs) associated with medial elastolysis and aortic root aneurysm. We aimed to reduce aortic elastolysis through decrease of MMP expression with decoy oligodeoxynucleotides (dODNs...