AP-1 Oligodeoxynucleotides Reduce Aortic Elastolysis in a Murine Model of Marfan Syndrome

• প্রধান লেখক: Rawa Arif (লেখক), Marcin Zaradzki (লেখক), Anca Remes (লেখক), Philipp Seppelt (লেখক), Reiner Kunze (লেখক), Hannes Schröder (লেখক), Simon Schwill (লেখক), Stephan M. Ensminger (লেখক), Peter N. Robinson (লেখক), Matthias Karck (লেখক), Oliver J. Müller (লেখক), Markus Hecker (লেখক), Andreas H. Wagner (লেখক), Klaus Kallenbach (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Elsevier, 2017-12-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Marfan syndrome is characterized by high expression of matrix metalloproteinases (MMPs) in aortic smooth muscle cells (AoSMCs) associated with medial elastolysis and aortic root aneurysm. We aimed to reduce aortic elastolysis through decrease of MMP expression with decoy oligodeoxynucleotides (dODNs...