Definition of the Neurotoxicity-Associated Metabolic Signature Triggered by Berberine and Other Respiratory Chain Inhibitors

• Main Authors: Ilinca Suciu (Author), Johannes Delp (Author), Simon Gutbier (Author), Julian Suess (Author), Lars Henschke (Author), Ivana Celardo (Author), Thomas U. Mayer (Author), Ivano Amelio (Author), Marcel Leist (Author)
• Format: Book
• Published: MDPI AG, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

To characterize the hits from a phenotypic neurotoxicity screen, we obtained transcriptomics data for valinomycin, diethylstilbestrol, colchicine, rotenone, 1-methyl-4-phenylpyridinium (MPP), carbaryl and berberine (Ber). For all compounds, the concentration triggering neurite degeneration correlate...