Continued exposure of anti-cancer drugs to human iPS cell-derived cardiomyocytes can unmask their cardiotoxic effects

• Main Authors: Kazuho Sakamoto (Author), Kohei Sakatoku (Author), Shintaro Sugimoto (Author), Nanami Iwasaki (Author), Yusuke Sano (Author), Masahiko Yamaguchi (Author), Junko Kurokawa (Author)
• Format: Book
• Published: Elsevier, 2019-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Although the cardiotoxicity of anti-cancer drugs is an important issue, the underlying mechanisms remain unknown. To develop a sensitive assay system for cardiotoxicity, we examined effects of anti-cancer drugs on contractile functions of human iPS cell-derived cardiomyocytes by using non-invasive m...