Verubulin (Azixa) Analogues with Increased Saturation: Synthesis, SAR and Encapsulation in Biocompatible Nanocontainers Based on Ca²⁺ or Mg²⁺ Cross-Linked Alginate

• Main Authors: Kseniya N. Sedenkova (Author), Denis N. Leschukov (Author), Yuri K. Grishin (Author), Nikolay A. Zefirov (Author), Yulia A. Gracheva (Author), Dmitry A. Skvortsov (Author), Yanislav S. Hrytseniuk (Author), Lilja A. Vasilyeva (Author), Elena A. Spirkova (Author), Pavel N. Shevtsov (Author), Elena F. Shevtsova (Author), Alina R. Lukmanova (Author), Vasily V. Spiridonov (Author), Alina A. Markova (Author), Minh T. Nguyen (Author), Alexander A. Shtil (Author), Olga N. Zefirova (Author), Alexander A. Yaroslavov (Author), Elena R. Milaeva (Author), Elena B. Averina (Author)
• Format: Book
• Published: MDPI AG, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tubulin-targeting agents attract undiminished attention as promising compounds for the design of anti-cancer drugs. Verubulin is a potent tubulin polymerization inhibitor, binding to colchicine-binding sites. In the present work, a series of verubulin analogues containing a cyclohexane or cyclohepta...