Compression-Induced Phase Transitions of Bicalutamide

• Main Authors: Joanna Szafraniec-Szczęsny (Author), Agata Antosik-Rogóż (Author), Justyna Knapik-Kowalczuk (Author), Mateusz Kurek (Author), Ewa Szefer (Author), Karolina Gawlak (Author), Krzysztof Chmiel (Author), Sebastian Peralta (Author), Krzysztof Niwiński (Author), Krzysztof Pielichowski (Author), Marian Paluch (Author), Renata Jachowicz (Author)
• Format: Book
• Published: MDPI AG, 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The formation of solid dispersions with the amorphous drug dispersed in the polymeric matrix improves the dissolution characteristics of poorly soluble drugs. Although they provide an improved absorption after oral administration, the recrystallization, which can occur upon absorption of moisture or...