Hydrogen Peroxide Mediates Artemisinin-Derived C-16 Carba-Dimer-Induced Toxicity of Human Cancer Cells

• Main Authors: Amanda L. Kalen (Author), Brett A. Wagner (Author), Ehab H. Sarsour (Author), Maneesh G. Kumar (Author), Jessica L. Reedy (Author), Garry R. Buettner (Author), Nabin C. Barua (Author), Prabhat C. Goswami (Author)
• Format: Book
• Published: MDPI AG, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study used a nitroaliphatic chemistry approach to synthesize a novel artemisinin-derived carba-dimer (AG-1) and determined its anti-proliferative effects in human normal and cancer cells. AG-1 treatments selectively inhibit proliferation of cancer cells compared to normal human fibroblasts. Com...