Redox-sensitive, PEG-shielded carboxymethyl PEI nanogels silencing MicroRNA-21, sensitizes resistant ovarian cancer cells to cisplatin

A series of branched polyethylenimine (PEI) modifications including PEGylation (PEG2k-PEI) for steric shielding, redox-sensitive crosslinking for synthesis PEG2k-PEI-ss nanogels and subsequent carboxymethylation (PEG2k-CMPEI-ss) for modulation of the polymer pka have been introduced for cellular del...

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Bibliographic Details
Main Authors: Sanaz Javanmardi (Author), Ali Mohammad Tamaddon (Author), Mahmoud Reza Aghamaali (Author), Ladan Ghahramani (Author), Samira Sadat Abolmaali (Author)
Format: Book
Published: Elsevier, 2020-01-01T00:00:00Z.
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