Succinate Supplement Elicited "Pseudohypoxia" Condition to Promote Proliferation, Migration, and Osteogenesis of Periodontal Ligament Cells

• Autori principali: Huimin Mao (Autore), Andi Yang (Autore), Yunhe Zhao (Autore), Lang Lei (Autore), Houxuan Li (Autore)
• Natura: Libro
• Pubblicazione: Hindawi Limited, 2020-01-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Most mesenchymal stem cells reside in a niche of low oxygen tension. Iron-chelating agents such as CoCl2 and deferoxamine have been utilized to mimic hypoxia and promote cell growth. The purpose of the present study was to explore whether a supplement of succinate, a natural metabolite of the tricar...