miR-130a activates the VEGFR2/STAT3/HIF1α axis to potentiate the vasoregenerative capacity of endothelial colony-forming cells in hypoxia

• Main Authors: Jasenka Guduric-Fuchs (Author), Edoardo Pedrini (Author), Judith Lechner (Author), Sarah E.J. Chambers (Author), Christina L. O'Neill (Author), Joana Mendes Lopes de Melo (Author), Varun Pathak (Author), Rachel H. Church (Author), Stuart McKeown (Author), James Bojdo (Author), Kiran J. Mcloughlin (Author), Alan W. Stitt (Author), Reinhold J. Medina (Author)
• Format: Book
• Published: Elsevier, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hypoxia modulates reparative angiogenesis, which is a tightly regulated pathophysiological process. MicroRNAs (miRNAs) are important regulators of gene expression in hypoxia and angiogenesis. However, we do not yet have a clear understanding of how hypoxia-induced miRNAs fine-tune vasoreparative pro...