Simultaneous determination of acetaminophen and oxycodone in human plasma by LC-MS/MS and its application to a pharmacokinetic study

• Главные авторы: Wei Lu (Автор), Shunbo Zhao (Автор), Meng Gong (Автор), Luning Sun (Автор), Li Ding (Автор)
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• Опубликовано: Elsevier, 2018-06-01T00:00:00Z.
• Предметы: article
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A simple and rapid liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for simultaneous determination of acetaminophen and oxycodone in human plasma. Acetaminophen-d4 and oxycodone-d3 were used as internal standards. The challenge encountered in the method de...