Positive Effects of PI3K/Akt Signaling Inhibition on PTEN and P53 in Prevention of Acute Lymphoblastic Leukemia Tumor Cells

• Main Authors: Elahe Naderali (Author), Behnaz Valipour (Author), Amir Afshin Khaki (Author), Jafar Soleymani Rad (Author), Alireza Alihemmati (Author), Mohammad Rahmati (Author), Hojjatollah Nozad Charoudeh (Author)
• Format: Book
• Published: Tabriz University of Medical Sciences, 2019-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: The PI3K/Akt signaling pathway regulates cell growth, proliferation and viability in hematopoietic cells. This pathway always dysregulates in acute lymphoblastic leukemia (ALL). PTEN and P53 are tumor suppressor genes correlated with PI3K/Akt signaling pathway, and both have a tight link in...