Obeticholic Acid Reduces Kidney Matrix Metalloproteinase Activation Following Partial Hepatic Ischemia/Reperfusion Injury in Rats

• Glavni autori: Giuseppina Palladini (Autor), Marta Cagna (Autor), Laura Giuseppina Di Pasqua (Autor), Luciano Adorini (Autor), Anna Cleta Croce (Autor), Stefano Perlini (Autor), Andrea Ferrigno (Autor), Clarissa Berardo (Autor), Mariapia Vairetti (Autor)
• Format: Knjiga
• Izdano: MDPI AG, 2022-04-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

We have previously demonstrated that the farnesoid X receptor (FXR) agonist obeticholic acid (OCA) protects the liver via downregulation of hepatic matrix metalloproteinases (MMPs) after ischemia/reperfusion (I/R), which can lead to multiorgan dysfunction. The present study investigated the capacity...