Clinical application of whole-genome sequencing in the management of extensively drug-resistant tuberculosis: a case report

• Main Authors: Bugwesa Z. Katale (Author), Sylvia Rofael (Author), Linzy Elton (Author), Erasto V. Mbugi (Author), Stella G. Mpagama (Author), Daphne Mtunga (Author), Maryjesca G. Mafie (Author), Peter M. Mbelele (Author), Charlotte Williams (Author), Happiness C. Mvungi (Author), Rachel Williams (Author), Gulinja A. Saku (Author), Joanitha A. Ruta (Author), Timothy D. McHugh (Author), Mecky I. Matee (Author)
• Format: Book
• Published: BMC, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Whole-genome sequencing (WGS)-based prediction of drug resistance in Mycobacterium tuberculosis has the potential to guide clinical decisions in the design of optimal treatment regimens. Methods We utilized WGS to investigate drug resistance mutations in a 32-year-old Tanzanian m...