Exploring structural and biological insights of TEAD through rational design and synthesis of niflumic acid derivatives

• Main Authors: Yong-Sung Choi (Author), Yoon-Jung Kim (Author), Yeram Jeon (Author), Jong Soon Kang (Author), Juhee Lee (Author), Eunmi Hong (Author), Young-Hoon Park (Author), Wantae Kim (Author), Boksik Cha (Author), Raok Jeon (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Transcriptional enhanced associate domain (TEAD) transcription factors undergo auto-palmitoylation, which is critical to mediate their function and maintain stability. Targeting the palmitate binding pocket of TEAD holds considerable promise for drug discovery, and it can be characterised into three...