Exploring structural and biological insights of TEAD through rational design and synthesis of niflumic acid derivatives

• Autori principali: Yong-Sung Choi (Autore), Yoon-Jung Kim (Autore), Yeram Jeon (Autore), Jong Soon Kang (Autore), Juhee Lee (Autore), Eunmi Hong (Autore), Young-Hoon Park (Autore), Wantae Kim (Autore), Boksik Cha (Autore), Raok Jeon (Autore)
• Natura: Libro
• Pubblicazione: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Transcriptional enhanced associate domain (TEAD) transcription factors undergo auto-palmitoylation, which is critical to mediate their function and maintain stability. Targeting the palmitate binding pocket of TEAD holds considerable promise for drug discovery, and it can be characterised into three...