End-to-end approach for the characterization and control of product-related impurities in T cell bispecific antibody preparations

• Main Authors: Laurent Larivière (Author), Julia Eva Krüger (Author), Thomas von Hirschheydt (Author), Tilman Schlothauer (Author), Katharine Bray-French (Author), Martin Bader (Author), Valeria Runza (Author)
• Format: Book
• Published: Elsevier, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Antibody-based T cell-activating biologics are promising therapeutic medicines being developed for a number of indications, mainly in the oncology field. Among those, T cell bispecific antibodies are designed to bind one tumor-specific antigen and the T cell receptor at the same time, leading to a r...