Shh Signaling from the Injured Lung Microenvironment Drives BMSCs Differentiation into Alveolar Type II Cells for Acute Lung Injury Treatment in Mice

• Main Authors: Mengyu Wu (Author), Jing Liu (Author), Shu Zhang (Author), Yi Jian (Author), Ling Guo (Author), Huacai Zhang (Author), Junwei Mi (Author), Guoxin Qu (Author), Yaojun Liu (Author), Chu Gao (Author), Qingli Cai (Author), Dalin Wen (Author), Di Liu (Author), Jianhui Sun (Author), Jianxin Jiang (Author), Hong Huang (Author)
• Format: Book
• Published: Hindawi Limited, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Alveolar type II (AT2) cells are key effector cells for repairing damaged lungs. Direct differentiation into AT2 cells from bone marrow mesenchymal stem cells (BMSCs) is a promising approach to treating acute lung injury (ALI). The mechanisms of BMSC differentiation into AT2 cells have not been dete...