RANKL+ senescent cells under mechanical stress: a therapeutic target for orthodontic root resorption using senolytics

• मुख्य लेखकों: Yue Zhou (लेखक), Aki Nishiura (लेखक), Hidetoshi Morikuni (लेखक), Wenqi Deng (लेखक), Toru Tsujibayashi (लेखक), Yoshihiro Momota (लेखक), Yuki Azetsu (लेखक), Masamichi Takami (लेखक), Yoshitomo Honda (लेखक), Naoyuki Matsumoto (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Nature Publishing Group, 2023-05-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract In dentistry, orthodontic root resorption is a long-lasting issue with no effective treatment strategy, and its mechanisms, especially those related to senescent cells, remain largely unknown. Here, we used an orthodontic intrusion tooth movement model with an L-loop in rats to demonstrate...