RANKL+ senescent cells under mechanical stress: a therapeutic target for orthodontic root resorption using senolytics

• Main Authors: Yue Zhou (Author), Aki Nishiura (Author), Hidetoshi Morikuni (Author), Wenqi Deng (Author), Toru Tsujibayashi (Author), Yoshihiro Momota (Author), Yuki Azetsu (Author), Masamichi Takami (Author), Yoshitomo Honda (Author), Naoyuki Matsumoto (Author)
• Format: Book
• Published: Nature Publishing Group, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract In dentistry, orthodontic root resorption is a long-lasting issue with no effective treatment strategy, and its mechanisms, especially those related to senescent cells, remain largely unknown. Here, we used an orthodontic intrusion tooth movement model with an L-loop in rats to demonstrate...