The enhancing effect and promoting mechanisms of the stereoisomeric monoterpene alcohol esters as enhancers for drugs with different physicochemical properties

• Main Authors: Heping Wang (Author), Yan Li (Author), Chunyan Wang (Author), Jing Wang (Author), Bo Ren (Author), Xiaona Li (Author), Mingzhu Li (Author), Dandan Geng (Author), Chensi Wu (Author), Ligang Zhao (Author)
• Format: Book
• Published: Elsevier, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

To explore the structure-activity connections of amphiphilic permeation enhancers containing the length of the hydrophobic chains as well as the properties of the polar head, O-acylgeraniol and O-acylnerol derivatives were synthesized from geraniol/nerol (cis-isomer of geraniol) and pharmaceutical e...