Temporal Dynamics of Clonal Evolution in Chronic Lymphocytic Leukemia with Stereotyped IGHV4-34/IGKV2-30 Antigen Receptors: Longitudinal Immunogenetic Evidence

• Main Authors: Lesley-Ann Sutton (Author), Efterpi Kostareli (Author), Evangelia Stalika (Author), Athanasios Tsaftaris (Author), Achilles Anagnostopoulos (Author), Nikos Darzentas (Author), Richard Rosenquist (Author), Kostas Stamatopoulos (Author)
• Format: Book
• Published: BMC, 2013-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Chronic lymphocytic leukemia (CLL) patients assigned to stereotyped subset 4 possess distinctive patterns of intraclonal diversification (ID) within their immunoglobulin (IG) genes. Although highly indicative of an ongoing response to antigen(s), the critical question concerning the precise...