Desensitization of cAMP Accumulation via Human β3-Adrenoceptors Expressed in Human Embryonic Kidney Cells by Full, Partial, and Biased Agonists

• Egile Nagusiak: Katerina Okeke (Egilea), Martina B. Michel-Reher (Egilea), Stavros Gravas (Egilea), Martin C. Michel (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2019-06-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

β3-Adrenoceptors couple not only to cAMP formation but, at least in some cell types, also to alternative signaling pathways such as phosphorylation of extracellular signal-regulated kinase (ERK). β3-Adrenoceptor agonists are used in long-term symptomatic treatment of the overactive bladder syndrome;...