Comparative Serum and Brain Pharmacokinetics of Quercetin after Oral and Nasal Administration to Rats as Lyophilized Complexes with β-Cyclodextrin Derivatives and Their Blends with Mannitol/Lecithin Microparticles

• Main Authors: Konstantina Manta (Author), Paraskevi Papakyriakopoulou (Author), Anna Nikolidaki (Author), Evangelos Balafas (Author), Nikolaos Kostomitsopoulos (Author), Sabrina Banella (Author), Gaia Colombo (Author), Georgia Valsami (Author)
• Format: Book
• Published: MDPI AG, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Quercetin (Que) is one of the most studied flavonoids with strong antioxidant properties ascribed to its ability to bind free radicals and inactivate them. However, the low solubility of the compound along with its inadequate absorption after oral administration limit its beneficial effects. Que...