Solid phase microextraction chemical biopsy tool for monitoring of doxorubicin residue during in vivo lung chemo-perfusion

• Main Authors: Barbara Bojko (Author), Nikita Looby (Author), Mariola Olkowicz (Author), Anna Roszkowska (Author), Bogumiła Kupcewicz (Author), Pedro Reck dos Santos (Author), Khaled Ramadan (Author), Shaf Keshavjee (Author), Thomas K. Waddell (Author), German Gómez-Ríos (Author), Marcos Tascon (Author), Krzysztof Goryński (Author), Marcelo Cypel (Author), Janusz Pawliszyn (Author)
• Format: Book
• Published: Elsevier, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Development of a novel in vivo lung perfusion (IVLP) procedure allows localized delivery of high-dose doxorubicin (DOX) for targeting residual micrometastatic disease in the lungs. However, DOX delivery via IVLP requires careful monitoring of drug level to ensure tissue concentrations of this agent...