PEGylation of mRNA by Hybridization of Complementary PEG-RNA Oligonucleotides Stabilizes mRNA without Using Cationic Materials

• Main Authors: Naoto Yoshinaga (Author), Mitsuru Naito (Author), Yoshihiro Tachihara (Author), Eger Boonstra (Author), Kensuke Osada (Author), Horacio Cabral (Author), Satoshi Uchida (Author)
• Format: Book
• Published: MDPI AG, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Messenger RNA (mRNA) delivery strategies are required to protect biologically fragile mRNA from ribonuclease (RNase) attacks to achieve efficient therapeutic protein expression. To tackle this issue, most mRNA delivery systems have used cationic components, which form electrostatically driven comple...