Validation of Mct8/Oatp1c1 dKO mice as a model organism for the Allan-Herndon-Dudley Syndrome

• Autors principals: Gandhari Maity-Kumar (Autor), Lisa Ständer (Autor), Meri DeAngelis (Autor), Sooyeon Lee (Autor), Anna Molenaar (Autor), Lore Becker (Autor), Lillian Garrett (Autor), Oana V. Amerie (Autor), Sabine M. Hoelter (Autor), Wolfgang Wurst (Autor), Helmut Fuchs (Autor), Annette Feuchtinger (Autor), Valerie Gailus-Durner (Autor), Cristina Garcia-Caceres (Autor), Ahmed E. Othman (Autor), Caroline Brockmann (Autor), Vanessa I. Schöffling (Autor), Katja Beiser (Autor), Heiko Krude (Autor), Piotr A. Mroz (Autor), Susanna Hofmann (Autor), Jan Tuckermann (Autor), Richard D. DiMarchi (Autor), Martin Hrabe de Angelis (Autor), Matthias H. Tschöp (Autor), Paul T. Pfluger (Autor), Timo D. Müller (Autor)
• Format: Llibre
• Publicat: Elsevier, 2022-12-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Objective: The Allan-Herndon-Dudley syndrome (AHDS) is a severe disease caused by dysfunctional central thyroid hormone transport due to functional loss of the monocarboxylate transporter 8 (MCT8). In this study, we assessed whether mice with concomitant deletion of the thyroid hormone transporters...