The antiepileptic drug valproic acid and other medium-chain fatty acids acutely reduce phosphoinositide levels independently of inositol in Dictyostelium

• Үндсэн зохиолчид: Pishan Chang (Зохиогч), Benoit Orabi (Зохиогч), Rania M. Deranieh (Зохиогч), Manik Dham (Зохиогч), Oliver Hoeller (Зохиогч), Jakob A. Shimshoni (Зохиогч), Boris Yagen (Зохиогч), Meir Bialer (Зохиогч), Miriam L. Greenberg (Зохиогч), Matthew C. Walker (Зохиогч), Robin S. B. Williams (Зохиогч)
• Формат: Ном
• Хэвлэсэн: The Company of Biologists, 2012-01-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

SUMMARY Valproic acid (VPA) is the most widely prescribed epilepsy treatment worldwide, but its mechanism of action remains unclear. Our previous work identified a previously unknown effect of VPA in reducing phosphoinositide production in the simple model Dictyostelium followed by the transfer of d...