The antiepileptic drug valproic acid and other medium-chain fatty acids acutely reduce phosphoinositide levels independently of inositol in Dictyostelium

• Main Authors: Pishan Chang (Author), Benoit Orabi (Author), Rania M. Deranieh (Author), Manik Dham (Author), Oliver Hoeller (Author), Jakob A. Shimshoni (Author), Boris Yagen (Author), Meir Bialer (Author), Miriam L. Greenberg (Author), Matthew C. Walker (Author), Robin S. B. Williams (Author)
• Format: Book
• Published: The Company of Biologists, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SUMMARY Valproic acid (VPA) is the most widely prescribed epilepsy treatment worldwide, but its mechanism of action remains unclear. Our previous work identified a previously unknown effect of VPA in reducing phosphoinositide production in the simple model Dictyostelium followed by the transfer of d...