Genetic Variation Putatively Associated with <i>Mycobacterium tuberculosis</i> Resistance to Perchlozone, a New Thiosemicarbazone: Clues from Whole Genome Sequencing and Implications for Treatment of Multidrug-Resistant Tuberculosis

Genetic Variation Putatively Associated with <i>Mycobacterium tuberculosis</i> Resistance to Perchlozone, a New Thiosemicarbazone: Clues from Whole Genome Sequencing and Implications for Treatment of Multidrug-Resistant Tuberculosis

Perchlozone ([PCZ] 4-thioureido-iminomethylpyridinium perchlorate) is a new thiosemicarbazone approved for the treatment of multidrug-resistant tuberculosis (MDR-TB) in Russia and some other countries. The <i>ethA</i> and <i>hadABC</i> mutations may confer PCZ resistance. At...

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Main Authors: Igor Mokrousov (Author), Anna Vyazovaya (Author), Gulnora Akhmedova (Author), Natalia Solovieva (Author), Eugeni Turkin (Author), Viacheslav Zhuravlev (Author)
Format: Book
Published: MDPI AG, 2020-10-01T00:00:00Z.
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