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Evaluation of the Effect of CYP2D6 Genotypes on Tramadol and <i>O</i>-Desmethyltramadol Pharmacokinetic Profiles in a Korean Population Using Physiologically-Based Pharmacokinetic Modeling

Tramadol is a &#956;-opioid receptor agonist and a monoamine reuptake inhibitor. <i>O</i>-desmethyltramadol (M1), the major active metabolite of tramadol, is produced by CYP2D6. A physiologically-based pharmacokinetic model was developed to predict changes in time-concentration profi...

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Main Authors: Hyeon-Cheol Jeong (Author), Soo Hyeon Bae (Author), Jung-Woo Bae (Author), Sooyeun Lee (Author), Anhye Kim (Author), Yoojeong Jang (Author), Kwang-Hee Shin (Author)
Format: Book
Published: MDPI AG, 2019-11-01T00:00:00Z.
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