Development, Characterization, Optimization, and In Vivo Evaluation of Methacrylic Acid-Ethyl Acrylate Copolymer Nanoparticles Loaded with Glibenclamide in Diabetic Rats for Oral Administration

• Main Authors: Omar Rodrigo Guadarrama-Escobar (Author), Ivonne Sánchez-Vázquez (Author), Pablo Serrano-Castañeda (Author), German Alberto Chamorro-Cevallos (Author), Isabel Marlen Rodríguez-Cruz (Author), Adalí Yisell Sánchez-Padrón (Author), Ericka Anguiano-Almazán (Author), Ma. Concepción Peña-Juárez (Author), Abraham Méndez-Albores (Author), Clara Luisa Domínguez-Delgado (Author), Crisóforo Mercado-Márquez (Author), Betsabé Rodríguez-Pérez (Author), José Juan Escobar-Chávez (Author)
• Format: Book
• Published: MDPI AG, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The methacrylic acid-ethyl acrylate copolymer nanoparticles were prepared using the solvent displacement method. The independent variables were the drug/polymer ratio, surfactant concentration, Polioxyl 40 hydrogenated castor oil, the added water volume, time, and stirring speed, while size, PDI, ze...