Development, Characterization, Optimization, and In Vivo Evaluation of Methacrylic Acid-Ethyl Acrylate Copolymer Nanoparticles Loaded with Glibenclamide in Diabetic Rats for Oral Administration

• Autori principali: Omar Rodrigo Guadarrama-Escobar (Autore), Ivonne Sánchez-Vázquez (Autore), Pablo Serrano-Castañeda (Autore), German Alberto Chamorro-Cevallos (Autore), Isabel Marlen Rodríguez-Cruz (Autore), Adalí Yisell Sánchez-Padrón (Autore), Ericka Anguiano-Almazán (Autore), Ma. Concepción Peña-Juárez (Autore), Abraham Méndez-Albores (Autore), Clara Luisa Domínguez-Delgado (Autore), Crisóforo Mercado-Márquez (Autore), Betsabé Rodríguez-Pérez (Autore), José Juan Escobar-Chávez (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2021-11-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

The methacrylic acid-ethyl acrylate copolymer nanoparticles were prepared using the solvent displacement method. The independent variables were the drug/polymer ratio, surfactant concentration, Polioxyl 40 hydrogenated castor oil, the added water volume, time, and stirring speed, while size, PDI, ze...