A Short-activating RNA Oligonucleotide Targeting the Islet β-cell Transcriptional Factor MafA in CD34+ Cells

• Main Authors: Vikash Reebye (Author), Pål Sætrom (Author), Paul J Mintz (Author), John J Rossi (Author), Noriyuki Kasahara (Author), Georgios Nteliopoulos (Author), Joanna Nicholls (Author), Abdelali Haoudi (Author), Myrtle Gordon (Author), Nagy A Habib (Author)
• Format: Book
• Published: Elsevier, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Upon functional loss of insulin producing islet β-cells, some patients with diabetes become dependent on life-long insulin supplementation therapy. Bioengineering surrogate insulin producing cells is an alternative replacement strategy. We have developed a novel approach using short-activating RNA o...