Dynamic changes in the mouse skeletal muscle proteome during denervation-induced atrophy

• Главные авторы: Franziska Lang (Автор), Sriram Aravamudhan (Автор), Hendrik Nolte (Автор), Clara Türk (Автор), Soraya Hölper (Автор), Stefan Müller (Автор), Stefan Günther (Автор), Bert Blaauw (Автор), Thomas Braun (Автор), Marcus Krüger (Автор)
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• Опубликовано: The Company of Biologists, 2017-07-01T00:00:00Z.
• Предметы: article
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Loss of neuronal stimulation enhances protein breakdown and reduces protein synthesis, causing rapid loss of muscle mass. To elucidate the pathophysiological adaptations that occur in atrophying muscles, we used stable isotope labelling and mass spectrometry to quantify protein expression changes ac...