Dynamic changes in the mouse skeletal muscle proteome during denervation-induced atrophy

• Main Authors: Franziska Lang (Author), Sriram Aravamudhan (Author), Hendrik Nolte (Author), Clara Türk (Author), Soraya Hölper (Author), Stefan Müller (Author), Stefan Günther (Author), Bert Blaauw (Author), Thomas Braun (Author), Marcus Krüger (Author)
• Format: Book
• Published: The Company of Biologists, 2017-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Loss of neuronal stimulation enhances protein breakdown and reduces protein synthesis, causing rapid loss of muscle mass. To elucidate the pathophysiological adaptations that occur in atrophying muscles, we used stable isotope labelling and mass spectrometry to quantify protein expression changes ac...