Adenomatous polyposis coli in cancer and therapeutic implications

• Main Authors: Olivia Noe (Author), Louis Filipiak (Author), Rachel Royfman (Author), Austin Campbell (Author), Leslie Lin (Author), Danae Hamouda (Author), Laura Stanbery (Author), John Nemunaitis (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Inactivating mutations of the adenomatous polyposis coli (APC) gene and consequential upregulation of the Wnt signaling pathway are critical initiators in the development of colorectal cancer (CRC), the third most common cancer in the United States for both men and women. Emerging evidence suggests...