Prospective Validation and Refinement of a Population Pharmacokinetic Model of Fludarabine in Children and Young Adults Undergoing Hematopoietic Cell Transplantation

• Main Authors: Jordan T. Brooks (Author), Belen P. Solans (Author), Ying Lu (Author), Sandhya Kharbanda (Author), Christopher C. Dvorak (Author), Nahal Lalefar (Author), Susie Long (Author), Ashish O. Gupta (Author), Biljana Horn (Author), Jatinder K. Lamba (Author), Liusheng Huang (Author), Beth Apsel-Winger (Author), Ron J. Keizer (Author), Rada Savic (Author), Janel Long-Boyle (Author)
• Format: Book
• Published: MDPI AG, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Fludarabine is a nucleoside analog with antileukemic and immunosuppressive activity commonly used in allogeneic hematopoietic cell transplantation (HCT). Several fludarabine population pharmacokinetic (popPK) and pharmacodynamic models have been published enabling the movement towards precision dosi...